Don’t think it really changes anything here. Calling preflop in position is marginal, probably not great with an offsuit hand. KQs is a call all day, but KQo is pretty weak.

Since SB’s 3-betting range is probably very tight to begin with, the exposed As doesn’t actually make their range much weaker, it just weights it away from AA/AK and towards other hands. The interesting part is that your hand also blocks AK, AQ, KK and QQ, so it’s sort of tough to really put villain on much of a range.

However, we obviously can’t assume that just because we have blockers and one Ace is dead it’s impossible for villain to have strong hands. In order to actually start thinking about changing our play here, we need to actually have reason to think villain can be 3-betting wider or 3-bet bluffing some frequency, but the problem is that most of villain’s wider 3-bets in that spot (AJ/AT) and most of their most likely 3-bet bluffs (Ax suited) are also blocked by the As, so we’re pretty much right back where we started.

I think the only thing losing the As really does is make it slightly more likely the SB has hands like 99-JJ, but it doesn’t really make life much easier for you here. The fact that the Ks becomes the nut flush draw in the event that 3 spades come out is almost a total non-factor, since 3 spades will come out very rarely – in fact, the reality that there’s one fewer spade in the deck probably makes it less of a good spot, not more.

Generally I think it’s over-complicating things a little to try to make decisions based on things like exposed cards when we haven’t yet established a clear expectation of what villain’s range actually is. I think “what is the SB’s likely 3-betting range here?” is a much more useful question to ask than “how does the exposed As affect the hand?”